Mechanochemical coupling of kinesin studied with the neck linker swing model

2006/01/24 by Yaogen Shu, Shu, Yaogen, Hualin Shi +1
Biochemistry, Genetics and Molecular Biology · #FOS: Biological sciences #Other Quantitative Biology (q-bio.OT) #q-bio.OT

paper · pdf · doi:10.48550/arxiv.q-bio/0601040

5pages

arxiv created 2006/01/24 · arxiv updated 2009/12/01

Abstract

We have proposed the neck linker swing model to investigate the mechanism of mechanochemical coupling of kinesin. The Michaelis-Menten-like curve for velocity vs ATP concentration at different loads has been obtained, which is in agreement with experiments. We have predicted that Michaelis constant doesn't increase monotonically and an elastic instability will happen with increasing of applied force.

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