A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features

2022/01/24 by Yasuhiro Kazuki, Feng Gao, Feng J. Gao +27 · 16 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Down syndrome and intellectual disability research #Genomics and Rare Diseases #Genomic variations and chromosomal abnormalities

paper · pdf · doi:10.1016/j.ajhg.2021.12.015

Citations

• Neuroanatomy of Down’s Syndrome: A High-Resolution MRI Study

Cited by

• Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells
• A new Down syndrome rat model races forward. [europepmc]
• Neurodevelopment in Down syndrome: Concordance in humans and models. [europepmc]
• Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model. [europepmc]
• Hypermetabolism in mice carrying a near-complete human chromosome 21. [europepmc]
• From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome. [europepmc]
• Ultrasonic vocalization phenotypes in the Ts65Dn and Dp(16)1Yey mouse models of Down syndrome. [europepmc]
• Transcriptional Interactions of Single B-Subgenome Chromosome with C-Subgenome in B. oleracea-nigra Additional Lines. [europepmc]
• Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model. [europepmc]
• Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome. [europepmc]
• Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model. [europepmc]
• Infantile Spasms in Pediatric Down Syndrome: Potential Mechanisms Driving Therapeutic Considerations. [europepmc]
• Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells. [europepmc]
• The Hallmarks of Aneuploidy in Cancer and Congenital Syndromes. [europepmc]
• Promoting Research Excellence in Down Syndrome: Proceedings of the 5th International Conference of the Trisomy 21 Research Society. [europepmc]
• Investigating Brain Alterations in the Dp1Tyb Mouse Model of Down Syndrome [europepmc]