Classification of Human Chromosome 21 Gene-Expression Variations in Down Syndrome: Impact on Disease Phenotypes

2007/08/08 by E. Aït Yahya-Graison, J. Aubert, Julie Aubert +20 · 25 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Down syndrome and intellectual disability research #Genomic variations and chromosomal abnormalities #Genomics and Rare Diseases

paper · pdf · doi:10.1086/520000

Citations

• Statistical significance for genomewide studies
• Gene-Expression Variation Within and Among Human Populations

Cited by

• The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics. [europepmc]
• Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. [europepmc]
• Down syndrome--recent progress and future prospects. [europepmc]
• Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development. [europepmc]
• Dosage compensation and the global re-balancing of aneuploid genomes. [europepmc]
• Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins. [europepmc]
• Inflammatory and Immunological parameters in adults with Down syndrome. [europepmc]
• Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes. [europepmc]
• miRNA-155 upregulation and complement factor H deficits in Down's syndrome. [europepmc]
• Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells. [europepmc]
• Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome. [europepmc]
• Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos. [europepmc]
• Genetic architecture of reciprocal CNVs. [europepmc]
• Translating dosage compensation to trisomy 21. [europepmc]
• Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome. [europepmc]
• The importance of understanding individual differences in Down syndrome. [europepmc]
• DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome. [europepmc]
• What people with Down Syndrome can teach us about cardiopulmonary disease. [europepmc]
• Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells. [europepmc]
• Integrated Quantitative Transcriptome Maps of Human Trisomy 21 Tissues and Cells. [europepmc]
• Aneuploidy and gene expression: is there dosage compensation? [europepmc]
• Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma. [europepmc]
• Metabolic Diseases and Down Syndrome: How Are They Linked Together? [europepmc]
• Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome. [europepmc]
• Ts66Yah, a mouse model of Down syndrome with improved construct and face validity. [europepmc]