Extreme Polygenicity of Complex Traits Is Explained by Negative Selection

2019/08/08 by Luke J. O’Connor, Luke J. O'Connor, Armin Schoech +5 · 311 citations
Biochemistry, Genetics and Molecular Biology · Psychology · #Artificial intelligence #Biology #Computer science #Evolution and Genetic Dynamics #Evolutionary biology #Genetic Associations and Epidemiology #Genetic Mapping and Diversity in Plants and Animals #Psychology #Selection (genetic algorithm)

paper · pdf · doi:10.1016/j.ajhg.2019.07.003

published in The American Journal of Human Genetics 105(3), 456-476 (Elsevier BV)

openalex publication_date 2019/08/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Citations

• Improved Heritability Estimation from Genome-wide SNPs
• Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
• 10 Years of GWAS Discovery: Biology, Function, and Translation

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