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High Throughput Computation of Reference Ranges of Biventricular Cardiac Function on the UK Biobank Population Cohort

2019/01/10 by Rahman Attar, Marco Pereanez, Marco Pereañez +17 · 1 citation
Computer Science · Engineering · Mathematics · Medicine · #FOS: Computer and information sciences #FOS: Electrical engineering #Image and Video Processing (eess.IV) #Machine Learning (cs.LG) #Machine Learning (stat.ML) #Machine Learning in Healthcare #Medical Imaging Techniques and Applications #Radiomics and Machine Learning in Medical Imaging #cs.LG #eess.IV #electronic engineering #information engineering #stat.ML

paper · pdf · doi:10.48550/arxiv.1901.03326

Accepted in STACOM workshop of MICCAI2018

arxiv created 2019/01/10 · openalex publication_date 2019/01/10 · arxiv updated 2019/01/14 · openalex created_date 2022/07/30 · openalex updated_date 2026/07/28

Abstract

The exploitation of large-scale population data has the potential to improve healthcare by discovering and understanding patterns and trends within this data. To enable high throughput analysis of cardiac imaging data automatically, a pipeline should comprise quality monitoring of the input images, segmentation of the cardiac structures, assessment of the segmentation quality, and parsing of cardiac functional indexes. We present a fully automatic, high throughput image parsing workflow for the analysis of cardiac MR images, and test its performance on the UK Biobank (UKB) cardiac dataset. The proposed pipeline is capable of performing end-to-end image processing including: data organisation, image quality assessment, shape model initialisation, segmentation, segmentation quality assessment, and functional parameter computation; all without any user interaction. To the best of our knowledge,this is the first paper tackling the fully automatic 3D analysis of the UKB population study, providing reference ranges for all key cardiovascular functional indexes, from both left and right ventricles of the heart. We tested our workflow on a reference cohort of 800 healthy subjects for which manual delineations, and reference functional indexes exist. Our results show statistically significant agreement between the manually obtained reference indexes, and those automatically computed using our framework.

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