Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction

2017/03/22 by Charline J. J. Gerard, Gilles Ferry, Gerard, Charline +17 · 1 citation
Biochemistry, Genetics and Molecular Biology · Materials Science · #Biomolecules (q-bio.BM) #Crystallization and Solubility Studies #Enzyme Structure and Function #FOS: Biological sciences #Protein purification and stability

paper · doi:10.48550/arxiv.1704.06301

openalex publication_date 2017/03/22 · openalex created_date 2019/07/30 · openalex updated_date 2026/07/28

Abstract

A microfluidic platform was used to address the problems of obtaining diffraction-quality crystals and crystal handling during transfer to the X-ray diffractometer. Crystallization conditions of a protein of pharmaceutical interest were optimized and X-ray data were collected both in situ and ex situ.

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• Biomolecular crystallization in microfluidic devices

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