2007/04/23 by Ashok Palaniappan, Palaniappan, Ashok
Biochemistry, Genetics and Molecular Biology · Chemistry · Mathematics · #Artificial intelligence #Biomolecules (q-bio.BM) #Classical mechanics #Computer science #Evolution and Genetic Dynamics #FOS: Biological sciences #Fourier analysis #Fourier transform #Mathematical Biology Tumor Growth #Mathematical analysis #Mathematics #Moment (physics) #Physics #Quantitative Methods (q-bio.QM) #Selection (genetic algorithm) #q-bio.BM #q-bio.QM #thermodynamics and calorimetric analyses
paper · pdf · doi:10.48550/arxiv.0704.2964
arxiv created 2007/04/23 · openalex publication_date 2007/04/23 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Secondary structure elements of many protein families exhibit differential conservation on their opposing faces. Amphipathic helices and beta-sheets by definition possess this property, and play crucial functional roles. This type of evolutionary trajectory of a protein family is usually critical to the functions of the protein family, as well as in creating functions within subfamilies. That is, differential conservation maintains properties of a protein structure related to its orientation, and that are important in packing, recognition, and catalysis. Here I define and formulate a new concept, called the selection moment, that detects this evolutionary process in protein sequences. A treatment of its various applications is detailed.