Discovery of Phylogenetic Relevant Y-chromosome Variants in 1000 Genomes Project Data

2013/10/24 by Chuan‐Chao Wang, Hui Li, Wang, Chuan-Chao +1
Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · #Forensic and Genetic Research #Genetic diversity and population structure #Chromosomal and Genetic Variations

paper · pdf · doi:10.48550/arxiv.1310.6590

Abstract

Current Y chromosome research is limited in the poor resolution of Y chromosome phylogenetic tree. Entirely sequenced Y chromosomes in numerous human individuals have only recently become available by the advent of next-generation sequencing technology. The 1000 Genomes Project has sequenced Y chromosomes from more than 1000 males. Here, we analyzed 1000 Genomes Project Y chromosome data of 1269 individuals and discovered about 25,000 phylogenetic relevant SNPs. Those new markers are useful in the phylogeny of Y chromosome and will lead to an increased phylogenetic resolution for many Y chromosome studies.

Related

• Hiding in plain sight: the Y chromosome and its reinvigorated role in evolutionary processes
• Introducing the Y-chromosomal Ancestral-like Reference Sequence—Improving the Capture of Human Evolutionary Information
• Convergence of Y chromosome STR haplotypes from different SNP haplogroups compromises accuracy of haplogroup prediction
• Natural Selection Reduced Diversity on Human Y Chromosomes
• Natural selection reduced diversity on human Y chromosomes