Relation between Aluminum Concentrations in Drinking Water and Alzheimer's Disease: An 8-year Follow-up Study
2000/07/01 by Virginie Rondeau, Daniel Commenges, D Commenges +4 · 28 citations
Agricultural and Biological Sciences · Medicine · Environmental Science · #Aluminum toxicity and tolerance in plants and animals #Alzheimer's disease research and treatments #Heavy Metal Exposure and Toxicity
paper · doi:10.1093/aje/152.1.59
Abstract
To investigate the effect of aluminum and silica in drinking water on the risk of dementia and Alzheimer's disease, the authors analyzed data from a large prospective cohort (Paquid), including 3,777 subjects aged 65 years and over living at home in 75 civil parishes in Gironde and Dordogne in southwestern France in 1988-1989. The subjects were followed for up for 8 years with an active search for incident cases of dementia or Alzheimer's disease. Mean exposure to aluminum and silica in drinking water was estimated in each area. The sample studied included 2,698 nondemented subjects at baseline, for whom components of drinking water and covariates were available. A total of 253 incident cases of dementia (with 17 exposed to high levels of aluminum), including 182 Alzheimer's disease (with 13 exposed to high aluminum levels), were identified. The relative risk of dementia adjusted for age, gender, educational level, place of residence, and wine consumption was 1.99 (95 percent CI: 1.20, 3.28) for subjects exposed to an aluminum concentration greater than 0.1 mg/liter. This result was confirmed for Alzheimer's disease (adjusted relative risk = 2.14, 95 percent CI: 1.21, 3.80). However, no dose-response relation was found. Inversely, the adjusted relative risk of dementia for subjects exposed to silica (> or = 11.25 mg/liter) was 0.74 (95 percent CI: 0.58, 0.96). These findings support the hypothesis that a high concentration of aluminum in drinking water may be a risk factor for Alzheimer's disease.
Citations
Cited by
- NMR spectroscopy of wastewater: A review, case study, and future potential
- Some aspects of astroglial functions and aluminum implications for neurodegeneration
- A Review of Epidemiologic Studies on Aluminum and Silica in Relation to Alzheimer's Disease and Associated Disorders
- Re: aluminum in drinking water and cognitive decline in elderly subjects: the Paquid cohort. [europepmc]
- A review of epidemiologic studies on aluminum and silica in relation to Alzheimer's disease and associated disorders. [europepmc]
- Environmentally relevant metal and transition metal ions enhance Fc epsilon RI-mediated mast cell activation. [europepmc]
- Maximum penalized likelihood estimation in a gamma-frailty model. [europepmc]
- Neurodegenerative diseases: an overview of environmental risk factors. [europepmc]
- Analysis of the effect of aluminum in drinking water and transferrin C2 allele on Alzheimer's disease. [europepmc]
- Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. [europepmc]
- Aluminum and silica in drinking water and the risk of Alzheimer's disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort. [europepmc]
- The neurotoxicity of environmental aluminum is still an issue. [europepmc]
- Influence of zinc on the biokinetics of (65)Zn in brain and whole body and its bio-distribution in aluminium-intoxicated rats. [europepmc]
- Environmental risk factors for dementia: a systematic review. [europepmc]
- Examining the Relationship between Trace Lithium in Drinking Water and the Rising Rates of Age-Adjusted Alzheimer's Disease Mortality in Texas. [europepmc]
- Comparative analysis of cognitive impairment prevalence and its etiological subtypes in a rural area of northern China between 2010 and 2015. [europepmc]
- Increased Aluminum Content in Certain Brain Structures is Correlated with Higher Silicon Concentration in Alcoholic Use Disorder. [europepmc]
- Aggregation-Induced Emission-Active Hydrazide-Based Probe: Selective Sensing of Al 3+ , HF 2 - , and Nitro Explosives. [europepmc]
- Multivalent ions and biomolecules: Attempting a comprehensive perspective. [europepmc]
- A Toxic Synergy between Aluminium and Amyloid Beta in Yeast. [europepmc]
- Separation of Excess Fluoride from Water Using Amorphous and Crystalline AlOOH Adsorbents. [europepmc]
- Effect of Parylene C on the Corrosion Resistance of Bioresorbable Cardiovascular Stents Made of Magnesium Alloy 'Original ZM10'. [europepmc]
- Optimization of the clinically approved mg-Zn alloy system through the addition of ca. [europepmc]
- Aluminium in the Human Brain: Routes of Penetration, Toxicity, and Resulting Complications. [europepmc]
- Comprehensive Regulation of Liquid-Liquid Phase Separation of Polypeptides. [europepmc]
- Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer's Disease: A Focus on Non-Coding RNAs. [europepmc]
- Fluorescence characteristics of dissolved organic matter (DOM) in bottled drinking water of different countries: A potential risk to public health. [europepmc]
- Heavy Metals Like Aluminum, Arsenic, Cadmium, Chromium, Copper, Iron, Lead, Manganese, Mercury, Nickel, and Zinc Polluting the Drinking Water: Their Individual Health Hazards. [europepmc]
Related