Tests for Trend and Dose Response: Misinterpretations and Alternatives

1992/01/01 by Malcolm Madure, Sander Greenland · 18 citations
Mathematics · #Statistical Methods in Clinical Trials

paper · doi:10.1093/oxfordjournals.aje.a116206

Abstract

Tests for overall trend, such as the Mantel extension test, are not tests for monotonic dose response. A survey of epidemiologic articles shows widespread misinterpretation of the Mantel extension test and overstatement of evidence for monotonic dose response when there are few exposed subjects. To properly evaluate the hypothesis that risk continues to increase with further increases in exposure, one must examine several statistics and estimates. Given sufficient data, nonparametric or polynomial regression analyses can provide more detailed dose-response information.

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