2021/04/30 by Hamdan Awan, Andreani D. Odysseos, Awan, Hamdan +5
Engineering · Biochemistry, Genetics and Molecular Biology · Computer Science · #Molecular Communication and Nanonetworks #Gene Regulatory Network Analysis #Quantum Computing Algorithms and Architecture
paper · pdf · doi:10.48550/arxiv.2104.14954
In this paper we consider the influence of intercellular communication on the\ndevelopment and progression of Glioblastoma Multiforme (GBM), a grade IV\nmalignant glioma which is defined by an interplay Grow i.e. self renewal and Go\ni.e. invasiveness potential of multiple malignant glioma stem cells. Firstly,\nwe performed wet lab experiments with U87 malignant glioma cells to study the\nnode-stem growth pattern of GBM. Next we develop a model accounting for the\nstructural influence of multiple transmitter and receiver glioma stem cells\nresulting in the node-stem growth structure of GBM tumour. By using information\ntheory we study different properties associated with this communication model\nto show that the growth of GBM in a particular direction (node to stem) is\nrelated to an increase in mutual information. We further show that information\nflow between glioblastoma cells for different levels of invasiveness vary at\ndifferent points between node and stem. These findings are expected to\ncontribute significantly in the design of future therapeutic mechanisms for\nGBM.\n