Pathologic Features of Breast Cancers in Women With Previous Benign Breast Disease
2001/03/01 by Timothy W. Jacobs, Celia Byrne, Graham A. Colditz +3 · 16 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Breast Lesions and Carcinomas #Breast Cancer Treatment Studies #Cancer and Skin Lesions
paper · pdf · doi:10.1309/up07-k3kd-25nl-d3m8
Abstract
To compare pathologic features of the cancers arising after different types of benign breast disease (BBD), we reviewed the invasive breast cancer slides of 169 women with a previous benign biopsy result. Lesions were categorized previously as nonproliferative, proliferative without atypia, or atypical hyperplasia. Pathologic features of the cancers were evaluated without knowledge of the previous BBD category. Estrogen and progesterone receptor immunohistochemistry was performed on available tissue blocks. The median times between a benign result and cancer were 100, 124, and 92 months for women with nonproliferative lesions, proliferative lesions without atypia, and atypical hyperplasia, respectively. Cancers in the 3 groups did not differ significantly in tumor size, axillary lymph node status, or histologic grade, and there was no significant difference in the distribution of histologic types of breast cancer. Lymphatic vessel invasion, extensive intraductal component, and hormone receptor status did not differ among BBD categories. The pathologic features of breast cancers that develop in women with a previous benign biopsy result do not vary according to the histologic category of the previous BBD.
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- Clinicopathologic features of breast cancers that develop in women with previous benign breast disease. [europepmc]
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- Associations of alcohol consumption with breast tissue composition. [europepmc]
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- Associations of Early-Life and Adult Anthropometric Measures with the Expression of Stem Cell Markers CD44, CD24, and ALDH1A1 in Women with Benign Breast Biopsies. [europepmc]
- Associations of stem cell markers CD44, CD24 and ALDH1A1 with mammographic breast density in women with benign breast biopsies. [europepmc]
- Associations of circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the expression of stem cell markers in benign breast tissue. [europepmc]
- Associations of Stem Cell Markers with Lobular Involution in Benign Breast Tissue. [europepmc]
- Associations of alcohol consumption with expression of CD44, CD24, and ALDH1A1 stem cell markers in benign breast biopsy samples. [europepmc]
- Birthweight, height, and body mass index in relation to the expression of stem cell markers among women with benign breast biopsies in the Nurses' Health Study II. [europepmc]
- Reliability of stromal markers multiplex immunofluorescent staining: pathologist assessment compared to quantitative image analysis [europepmc]
- The origins of oestrogen receptor negative breast cancer [europepmc]
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