2023/06/22 by Batuhan E. Kaynak, Mohammed Alkhaled, Kaynak, Batuhan E. +7
Chemistry · Engineering · Physics and Astronomy · #Advanced Chemical Sensor Technologies #Applied Physics (physics.app-ph) #Biological Physics (physics.bio-ph) #Chemical Physics (physics.chem-ph) #FOS: Physical sciences #Instrumentation and Detectors (physics.ins-det) #Mass Spectrometry Techniques and Applications #Mechanical and Optical Resonators
paper · pdf · doi:10.48550/arxiv.2306.13227
openalex publication_date 2023/06/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03
Weighing particles above MegaDalton mass range has been a persistent challenge in commercial mass spectrometry. Recently, nanoelectromechanical systems-based mass spectrometry (NEMS-MS) has shown remarkable performance in this mass range, especially with the advance of performing mass spectrometry under entirely atmospheric conditions. This advance reduces the overall complexity and cost, while improving the limit of detection. However, this technique required the tracking of two mechanical modes, and the accurate knowledge of mode shapes which may deviate from their ideal values especially due to air damping. Here, we used a NEMS architecture with a central platform, which enables the calculation of mass by single mode measurements. Experiments were conducted using polystyrene and gold nanoparticles to demonstrate the successful acquisition of mass spectra using a single mode, with improved areal capture efficiency. This advance represents a step forward in NEMS-MS, bringing it closer to becoming a practical application for mass sensing of nanoparticles.