The pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers

2009/08/27 by Kenneth DR Setchell, Kenneth D.R. Setchell, Xueheng Zhao +5 · 25 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioactive natural compounds #Bioavailability #Biochemistry #Chemistry #Daidzein #Diastereomer #Enantiomer #Endocrinology #Equol #Genistein #Hops Chemistry and Applications #Isoflavones #Medicine #Metabolite #Pharmacokinetics #Pharmacology #Phytoestrogen effects and research #Stereochemistry

paper · pdf · doi:10.3945/ajcn.2009.27981

openalex publication_date 2009/08/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Citations

• Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans
• Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverage

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• Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: A review of the data and identification of knowledge gaps
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• Analysis of urinary estrogens, their oxidized metabolites, and other endogenous steroids by benchtop orbitrap LCMS versus traditional quadrupole GCMS. [europepmc]
• Equol production changes over time in postmenopausal women. [europepmc]
• The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems. [europepmc]
• Endogenous and exogenous equol are antiestrogenic in reproductive tissues of apolipoprotein e-null mice. [europepmc]
• Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments. [europepmc]
• Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles in vitro. [europepmc]
• Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro. [europepmc]
• Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor β-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women. [europepmc]
• Screening dietary biochanin A, daidzein, equol and genistein for their potential to increase DHA biosynthesis in rainbow trout (Oncorhynchus mykiss). [europepmc]
• Safety and feasibility of estrogen receptor-β targeted phytoSERM formulation for menopausal symptoms: phase 1b/2a randomized clinical trial. [europepmc]
• Characterization and bioactivity of self-assembled anti-angiogenic chondroitin sulfate-ES2-AF nanoparticle conjugate. [europepmc]
• Flavonoid consumption and cardiometabolic health: Potential benefits due to foods, supplements, or biomarkers? [europepmc]
• Effects of Smoking on Inflammatory Markers in a Healthy Population as Analyzed via the Gut Microbiota. [europepmc]
• Phytoestrogens (Resveratrol and Equol) for Estrogen-Deficient Skin-Controversies/Misinformation versus Anti-Aging In Vitro and Clinical Evidence via Nutraceutical-Cosmetics. [europepmc]
• Use of Physiologically Based Pharmacokinetic Modeling to Predict Human Gut Microbial Conversion of Daidzein to S-Equol. [europepmc]
• Structural and Functional Alterations of Gut Microbiota in Males With Hyperuricemia and High Levels of Liver Enzymes. [europepmc]
• Dietary Isoflavone Aglycons from Soy Germ Pasta Improves Reproductive Performance of Aging Hens and Lowers Cholesterol Levels of Egg Yolk. [europepmc]
• Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone. [europepmc]
• Recent progress in DNA methyltransferase inhibitors as anticancer agents. [europepmc]
• Interplay between Phytochemicals and the Colonic Microbiota. [europepmc]
• Polyphenol-Derived Microbiota Metabolites and Cardiovascular Health: A Concise Review of Human Studies. [europepmc]
• Maresin-1 and S-Equol as Emerging Metabolic Biomarkers in Gestational Diabetes-Associated Inflammation. [europepmc]
• Bioactive Phenolic Compounds in Extra Virgin Olive Oil: Implications for Cardiovascular Health. [europepmc]