2007/06/04 by Óscar Sotolongo‐Grau, Sotolongo-Grau, O., Daniel Rodríguez Pérez +7
Mathematics · Medicine · #Cancer Cells and Metastasis #Cancer Immunotherapy and Biomarkers #FOS: Biological sciences #Mathematical Biology Tumor Growth #Populations and Evolution (q-bio.PE)
paper · pdf · doi:10.48550/arxiv.0706.0418
openalex publication_date 2007/06/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
A dynamical system model for tumor -- immune system interaction together with a method to mimic radiation therapy are proposed. A large population of virtual patients is simulated following an ideal radiation treatment. A characteristic parameter, the Immune System -- Tumor Efficiency Rate (ISTER), is introduced. ISTER dependence of treatment success and other features is studied. Statistical results allow us to give a patient classification scheme. Radiotherapy treatment biological effective dose (BED) is thus optimized based on the patient physical condition, following the ALARA (As Low As Reasonably Achievable) criterion.