2024/08/07 by Buonfiglio, Valentina, Zagli, Niccolò, Pertici, Irene +3
#Biomolecules (q-bio.BM) #FOS: Biological sciences #FOS: Physical sciences #Populations and Evolution (q-bio.PE) #Soft Condensed Matter (cond-mat.soft) #Statistical Mechanics (cond-mat.stat-mech) #Tissues and Organs (q-bio.TO)
paper · doi:10.48550/arxiv.2408.03676
A data fitting procedure is devised and thoroughly tested to provide self-consistent estimates of the relevant mechanokinetic parameters involved in a plausible scheme underpinning the output of an ensemble of myosin II molecular motors mimicking the muscle contraction. The method builds on a stochastic model accounting for the force exerted by the motor ensemble operated both in the low and high force-generating regimes corresponding to different temperature ranges. The proposed interpretative framework is successfully challenged against simulated data, meant to mimic the experimental output of a unidimensional synthetic nanomachine powered by pure muscle myosin isoforms.