2012/10/16 by Ajit Singh, John T. Halloran, Singh, Ajit P. +7 · 1 citation
Chemistry · Biochemistry, Genetics and Molecular Biology · #Advanced Proteomics Techniques and Applications #Mass Spectrometry Techniques and Applications #Metabolomics and Mass Spectrometry Studies
paper · pdf · doi:10.48550/arxiv.1210.4904
Shotgun proteomics is a high-throughput technology used to identify unknown\nproteins in a complex mixture. At the heart of this process is a prediction\ntask, the spectrum identification problem, in which each fragmentation spectrum\nproduced by a shotgun proteomics experiment must be mapped to the peptide\n(protein subsequence) which generated the spectrum. We propose a new algorithm\nfor spectrum identification, based on dynamic Bayesian networks, which\nsignificantly outperforms the de-facto standard tools for this task: SEQUEST\nand Mascot.\n