A viable hypomorphic mutation in the mitochondrial ribosome subunit, MRPS-31, exhibits mitochondrial dysfunction in C. elegans

2024/09/11 by Kylie M Jozwik, James P Held, Chloe A Hecht +1
Biochemistry, Genetics and Molecular Biology · #RNA modifications and cancer #Mitochondrial Function and Pathology #Genomics and Rare Diseases

paper · doi:10.17912/micropub.biology.001344

Abstract

and impact on organismal development, providing a valuable model for further study of the mitoribosome.

Related

• Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans
• Mitochondria-ER contact site components regulate the formation and localization of specialized high-capacity mitochondria in the C. elegans anchor cell.
• Programmed cell death throughout life influences the longevity of a defective mitochondrial mutant in C. elegans
• Insertion of mNeonGreen into the variable domain of DRP-1 permits visualization of functional endogenous protein
• Mitochondrial polarization and redox homeostasis couple glycolysis-to-OXPHOS metabolic rewiring to lifespan extension in C. elegans