The Biologic Clock: The Mitochondria?

1972/04/01 by DENHAM HARMAN, Denham Harman · 38 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Mitochondrial Function and Pathology #Genetics, Aging, and Longevity in Model Organisms #Birth, Development, and Health

paper · doi:10.1111/j.1532-5415.1972.tb00787.x

Abstract

ABSTRACT: The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen consumption, which ultimately causes death.

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