2014/12/01 by Terri R. Fried, John R. O’Leary, John O'Leary +4 · 722 citations
Medicine · #Beers Criteria #Dementia and Cognitive Impairment Research #Geriatrics #Gerontology #Intensive care medicine #MEDLINE #Medication Adherence and Compliance #Medicine #Older people #Pharmaceutical Practices and Patient Outcomes #Polypharmacy #Psychiatry
paper · open access · doi:10.1111/jgs.13153
published in Journal of the American Geriatrics Society 62(12), 2261-2272 (Wiley)
openalex publication_date 2014/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
OBJECTIVES: To summarize evidence regarding the health outcomes associated with polypharmacy, defined as number of prescribed medications, in older community-dwelling persons. DESIGN: Systematic review of MEDLINE (OvidSP 1946 to May, Week 3, 2014). SETTING: Community. PARTICIPANTS: Observational studies examining health outcomes according to number of prescription medications taken. MEASUREMENTS: Association between number of medications and health outcomes. Because of the importance of comorbidity as a potential confounder of the relationship between polypharmacy and health outcomes, articles were assessed regarding the quality of their adjustment for confounding. RESULTS: Of the 50 studies identified, the majority that were rated good in terms of their adjustment for comorbidity demonstrated relationships between polypharmacy and a range of outcomes, including falls, fall outcomes, fall risk factors, adverse drug events, hospitalization, mortality, and measures of function and cognition. However, a number of these studies failed to demonstrate associations, as did a substantial proportion of studies rated fair or poor. CONCLUSION: Data are mixed regarding the relationship between polypharmacy, considered in terms of number of medications, and adverse outcomes in community-dwelling older persons. Because of the challenge of confounding, randomized controlled trials of medication discontinuation may provide more-definitive evidence regarding this relationship than observational studies can provide.