2021/11/05 by Debomita Chakraborty, Raghunathan Rengaswamy, Chakraborty, Debomita +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · Computer Science · #Emerging Technologies (cs.ET) #Evolutionary Algorithms and Applications #FOS: Biological sciences #FOS: Computer and information sciences #Gene Regulatory Network Analysis #Gene expression and cancer classification #Molecular Networks (q-bio.MN)
paper · pdf · doi:10.48550/arxiv.2111.04508
openalex publication_date 2021/11/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Genetic circuit design is a well-studied problem in synthetic biology. Ever since the first genetic circuits -- the repressilator and the toggle switch -- were designed and implemented, many advances have been made in this area of research. The current review systematically organizes a number of key works in this domain by employing the versatile framework of generalized morphological analysis. Literature in the area has been mapped based on (a) the design methodologies used, ranging from brute-force searches to control-theoretic approaches, (b) the modelling techniques employed, (c) various circuit functionalities implemented, (d) key design characteristics, and (e) the strategies used for the robust design of genetic circuits. We conclude our review with an outlook on multiple exciting areas for future research, based on the systematic assessment of key research gaps that have been readily unravelled by our analysis framework.