The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment
2005/03/30 by Ziad S. Nasreddine, Ziad Nasreddine, Natalie A. Phillips +6 · 215 citations
Medicine · Health Professions · #Dementia and Cognitive Impairment Research #Intensive Care Unit Cognitive Disorders #Older Adults Driving Studies
paper · doi:10.1111/j.1532-5415.2005.53221.x
Abstract
OBJECTIVES: To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia. DESIGN: Validation study. SETTING: A community clinic and an academic center. PARTICIPANTS: Ninety-four patients meeting MCI clinical criteria supported by psychometric measures, 93 patients with mild Alzheimer's disease (AD) (Mini-Mental State Examination (MMSE) score > or =17), and 90 healthy elderly controls (NC). MEASUREMENTS: The MoCA and MMSE were administered to all participants, and sensitivity and specificity of both measures were assessed for detection of MCI and mild AD. RESULTS: Using a cutoff score 26, the MMSE had a sensitivity of 18% to detect MCI, whereas the MoCA detected 90% of MCI subjects. In the mild AD group, the MMSE had a sensitivity of 78%, whereas the MoCA detected 100%. Specificity was excellent for both MMSE and MoCA (100% and 87%, respectively). CONCLUSION: MCI as an entity is evolving and somewhat controversial. The MoCA is a brief cognitive screening tool with high sensitivity and specificity for detecting MCI as currently conceptualized in patients performing in the normal range on the MMSE.
Cited by
- Effect of intensive blood pressure control on subtypes of mild cognitive impairment and risk of progression from <scp>SPRINT</scp> study
- Normal-tension glaucoma is associated with cognitive impairment
- Fatigue in Post-COVID-Condition is accompanied by hypoperfusion of right-occipital areas
- Vitamin D Supplementation and Muscle Power, Strength and Physical Performance in Older Adults: A Randomized Controlled Trial
- Patient and caregiver contributions to self-care in multiple chronic conditions: A multilevel modelling analysis
- Outcomes of home‐based primary care for homebound older adults: A randomized clinical trial
- Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson’s disease
- Prevention of Early Postoperative Decline: A Randomized, Controlled Feasibility Trial of Perioperative Cognitive Training
- Demyelination and Cognitive Performance in Long COVID Patients with Insomnia and/or Depression
- Assessing mTBI-related brain changes: insights from bi-exponential and tri-exponential intravoxel incoherent motion (IVIM) MRI models
- Intensive Blood-Pressure Control for the Prevention of Major Cardiovascular Events in Patients with Type 2 Diabetes: Rationale, Design and Baseline Characteristics of the OPTIMAL-DIABETES Randomized Trial
- Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome
- Interdisziplinäres, kollaboratives D-A-CH Konsensus-Statement zur Diagnostik und Behandlung von Myalgischer Enzephalomyelitis/Chronischem Fatigue-Syndrom
- Better speech-in-noise comprehension is associated with enhanced neural speech tracking in older adults with hearing impairment
- Linking structural and functional changes during healthy aging and semantic dementia using multilayer brain network analysis
- Reduced distractor filtering with age: Evidence from the distractor positivity ERP
- The frequency of negative automatic thoughts may predict near-term suicide attempt in high-risk patients
- Social Networks and Cognitive Function: An Evaluation of Social Bridging and Bonding Mechanisms
- An Empirical Comparison of Different Models of Active Aging in Canada: The International Mobility in Aging Study
- Effects of bupropion and repetitive transcranial magnetic stimulation (rTMS) on sexual function, depression severity and cognitive performance in individuals with major depressive disorder – results from a double-blind, sham-controlled randomized intervention
- Dysfunctional large-scale networks linking PTSD and cognitive impairment
- Longitudinal Cognitive Changes in Cerebral Small Vessel Disease
- Nonalcoholic Wernicke-Korsakoff Syndrome Resulting From Psychosis
- Defining and validating a short form Montreal Cognitive Assessment (s-MoCA) for use in neurodegenerative disease
- Immunoadsorption Versus Sham Treatment for Post-COVID Syndrome: A Randomised Sham-Controlled Crossover Trial
- Upregulation of the parietal cortex improves freezing of gait in Parkinson's disease
- The relationship between neurofilament light chain and cognition in neurological disorders: A scoping review
- Factors associated with reduction in quality of life after SARS-CoV-2 infection
- Retinal Microvasculature Changes Linked to Executive Function Impairment after COVID-19
- Discovering Hidden Links: Harnessing Similarity Network Fusion to Reveal Common Clusters in Healthy Aging, Mild Cognitive Impairment, and Dementia
- Vascular Contributions to Cognitive Impairment and Dementia
- Tadalafil Treatment in Patients With Cerebral Small Vessel Disease: The ETLAS-2 Randomized Clinical Trial
- Acute hypoxaemic respiratory failure after treatment with lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal: long-term outcomes from the REST randomised trial
- Breaking down unitization: Is the whole greater than the sum of its parts?
- Neural state changes during movie watching relate to episodic memory in younger and older adults
- Beyond who, what, and where: Findings from two experiments on age group differences in narrative elaborateness of autobiographical events
- Impaired perceptual discrimination of complex objects in older adults at risk for dementia
- Parameter-efficient Prompt Tuning of Vision Foundation Model With Adaptive Focal Loss for Interpretable MCI Screening
- First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders
- The Effect of Creatine and Coenzyme Q10 Combination Therapy on Mild Cognitive Impairment in Parkinson's Disease
- Post-viral fatigue in COVID-19: A review of symptom assessment methods, mental, cognitive, and physical impairment
- A Whole-Body Exercise Test to Assess Cardiorespiratory Fitness across the Stroke Recovery Continuum
- Applications of Artificial Intelligence to aid detection of dementia: a narrative review on current capabilities and future directions
- SimulScan and Partial Least Squares: Visualizing Swallowing Through Functional and Dynamic Imaging Correlations
- Examining neuroimaging biomarkers, plasma biomarkers and cognitive functions in patients with recovered COVID-19 infection: a multicentre study using 7T MRI
- White Matter Matters: A Magnetic Resonance Imaging Study with Clinical Correlates in Primary Brain Calcification
- Physical activity may protect myelin via modulation of high‐density lipoprotein
- Learning the progression and clinical subtypes of Alzheimer's disease from longitudinal clinical data
- Epidemiology of amyotrophic lateral sclerosis in Southern Germany
- From Play to Detection: Mini-SPACE as a Serious Game for Unsupervised Cognitive Impairment Screening
- Sensory system-specific associations between brain structure and balance
- Individualized mapping of functional brain networks in older adulthood
- ActiTect: A Generalizable Machine Learning Pipeline for REM Sleep Behavior Disorder Screening through Standardized Actigraphy
- Predicting Cognitive Assessment Scores in Older Adults with Cognitive Impairment Using Wearable Sensors
- Rehabilitation and Return-to-Work of Patients Acquiring COVID-19 in the Workplace: A Study Protocol for an Observational Cohort Study
- Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease
- Association of PPP2R1A with Alzheimer's disease and specific cognitive domains
- Randomized Controlled Trial of Social Ballroom Dancing and Treadmill Walking: Preliminary Findings on Executive Function and Neuroplasticity From Dementia-at-Risk Older Adults
- Aging of resting-state functional connectivity in amateur singers, instrumentalists and controls
- Cardiorespiratory exercise and self-management early after stroke to increase daily physical activity: results from a stepped-wedge cluster randomised trial
- Go baby go café: a case study on an immersive rehabilitation environment to improve functional outcomes and quality of life
- Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan
- Effectiveness of an avatar educational application for improving heart failure patients’ knowledge and self‐care behaviors: A pragmatic randomized controlled trial
- Temporal Lobe Epilepsy Perturbs the Brain‐Wide Excitation‐Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction
- Altered brain iron content and deposition rate in Huntington’s disease as indicated by quantitative susceptibility MRI
- Effect of acceptance and commitment therapy‐based interventions on mental health and cognitive impairment for patients with advanced colorectal cancer
- 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
- The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds
- Semantic memory network resilience in aging: The role of abstract and semantically diverse words
- Intrinsic functional connectivity in the default mode network predicts mnemonic discrimination: A connectome‐based modeling approach
- Experience-induced plasticity in the attention system of healthy adults practising musical or non-musical activities
- Adverse and compensatory neurophysiological slowing in Parkinson’s disease
- Gender differences in associations between spousal cognitive decline and marital strain: Evidence from the U.S. older couples
- Functional Connectivity Is Dominated by Aperiodic, Rather Than Oscillatory, Coupling
- The ageing of the social mind: replicating the preservation of socio-affective and the decline of socio-cognitive processes in old age
- Circulatory dietary and gut-derived metabolites predict early cognitive decline
- Peripheral Mitochondrial Energetics are Associated with Cortical Neurophysiological Alterations in Alzheimer’s Disease
- Smartphone-based detection of subtle memory decline in prodromal Alzheimer’s disease
- Aberrant information flow within resting-state triple network model in schizophrenia-An EEG effective connectivity study
- Effect of Telerehabilitation-Based and Face-to-Face Core Stabilization Exercises on Core Muscle Thickness and Functional Capacity in Asymptomatic Individuals: A Randomized Trial
- Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial
- Drawing a line?—Visuo-constructive function as discriminator between healthy individuals, subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease and predictor of disease progress compared to a multimodal approach
- Is emotion regulation associated with cancer-related psychological symptoms?
- Preliminary effects of a modified Otago Exercise Program on metabolic, cellular, and epigenetic biomarkers in people living with dementia: A pilot randomized controlled trial
- Cognitive Impairment in MASLD is associated with Amygdala-Related Connectivity Dysfunction in the Prefrontal and Sensory Cortex
- Association Between Enlarged Perivascular Spaces and Early Acute Ischemic Stroke with Cognitive Impairment: A Cross-Sectional Study
- Neural Correlates of Menopausal Symptoms Revealed by Emotion-Related fNIRS Activity
- A re‐examination of Montreal Cognitive Assessment (MoCA) cutoff scores
- Brief cognitive screening instruments: an update
- Sex-Specific Contributions to Single- and Dual-Task Walking in Adults at Risk of Alzheimer Disease and Related Dementias
- Pilot Testing of Tone Dance: A Culturally Adapted Group-Based Physical Activity Program for Older Adults With Subjective Cognitive Decline
- Multidimensional Effects of Mind–Body Exercise on Cognitive Function, Physical Function, and Body Composition in Older Adults With Mild Cognitive Impairment: A 12-Week Randomized Controlled Trial
- Autobiographical memory and well-being in aging: The central role of semantic self-images
- Cognitive domain harmonization and cocalibration in studies of older adults.
- The continued influence effect: Examining how age, retraction, and delay impact inferential reasoning
- Mild Cognitive Impairment in Geriatrics
- Cognitive assessment in stroke: feasibility and test properties using differing approaches to scoring of incomplete items
- A Scoping Review on Conversational Memory and Characteristics of Conversations in Alzheimer's Disease
- Individual and dyadic correlates of emotion perception performance in older couples
- Hand Grip Strength as a Predictive Tool for Upper Extremity Functionality, Balance, and Quality of Life in People With Multiple Sclerosis
- Disentangling Event-Related Potential and Oscillatory Sources using Time- and Frequency-Domain Source Imaging
- Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease
- High-resolution structural connectivity mediates age-related differences in functional connectivity and fluid cognition
- A passive and objective measure of recognition memory in mild cognitive impairment using Fastball memory assessment
- Real-world environmental enrichment rehabilitation paradigm in people with severe traumatic brain injury: a pilot feasibility study
- Cross-Enhanced Multimodal Fusion of Eye-Tracking and Facial Features for Alzheimer's Disease Diagnosis
- A Comparison of Cardiopulmonary Exercise Testing and Shuttle Walk Test in Older Adults With Amnestic Mild Cognitive Impairment
- Delirium in the Elderly
- Depressive symptoms interact with CSF levels of p-tau in predicting cognitive performance in the early stages of Parkinson's disease
- Working Memory Functional Connectivity Analysis for Dementia Classification using EEG
- Cortical sensory aging is layer-specific
- Amyloid-beta-targeting monoclonal antibodies for people with mild cognitive impairment or mild dementia due to Alzheimer’s disease
- Wearable devices for patient monitoring in the intensive care unit
- Covert Vascular Brain Injury and Cognitive Dysfunction Among Chinese Adults Living in Canada and China
- Real-life cognitive functioning after acquired brain injury: An experience sampling study
- Enhanced mind-matter interactions following rTMS induced frontal lobe inhibition
- DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease
- Variation in Neurodegeneration‐Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida
- Multidisciplinary Allied Health Reablement Model of Care for Older People in Residential Aged Care and Community Settings: Mixed-Methods Evaluation
- The effectiveness of real‐life cognitive and physical interventions on cognitive functioning in healthy older adults: A systematic review of the effects of education and training duration
- Incidence of Visuospatial Neglect in Acute Stroke: Assessment and Stroke Characteristics in an Unselected 1-Year Cohort
- Periodontal Indices as Predictors of Cognitive Decline: Insights from the PerioMind Colombia Cohort
- Brain network dynamics associated with intentional weight loss in older adults
- Deep Learning-Based Detection of Cognitive Impairment from Passive Smartphone Sensing with Routine-Aware Augmentation and Demographic Personalization
- A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice
- Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study
- Long-Term Dementia Risk in Parkinson Disease
- Welcoming back my arm: affective touch increases body ownership following right-hemisphere stroke
- Coffee Consumption Correlates With Better Cognitive Performance in Patients With a High Incidence for Stroke
- Teasing apart time reference-related encoding and retrieval deficits in aphasia: evidence from Greek, Russian, Italian and English
- Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial
- Inflammation‐Triggered Enlargement of Choroid Plexus in Subacute <scp>COVID</scp>‐19 Patients with Neurological Symptoms
- Effect of famotidine on cognitive and behavioral dysfunctions induced in post-COVID-19 infection: A randomized, double-blind, and placebo-controlled study
- Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
- Reduced Adenosine Triphosphate-to-Phosphocreatine Ratios in Neuropsychiatric Post-COVID Condition: Evidence From 31P Magnetic Resonance Spectroscopy
- Multivariable analysis of myokines as biomarkers of frailty in females
- Machine Learning and AI Applied to fNIRS Data Reveals Novel Brain Activity Biomarkers in Stable Subclinical Multiple Sclerosis
- Loudness perception and speech intensity control in Parkinson's disease
- An exploratory model of speech intelligibility for healthy aging based on phonatory and articulatory measures
- Age-specific relationship between the modulation of brain dynamics in response to task demands and bimanual performance
- Dual-task performance during the Timed Up and Go test in Parkinson's disease - the impact of freezing and cognition
- EEG changes associated with hallucinations caused by Charles Bonnet Syndrome
- Autoimmune psychosis: Psychopathological patterns and outcome after immunotherapy
- Plant-Based Diets and Cognitive Outcomes: A Systematic Review and Meta-analysis
- Montreal Cognitive Assessment (MoCA) use in general practice for the early detection of cognitive impairment: a feasibility study
- To what extent do cataracts and cataract surgery change perception?
- The role of virtual reality-based cognitive training in enhancing motivation and cognitive functions in individuals with chronic stroke
- Accelerating the Delivery of Psychological Therapies After Stroke: A Feasibility Stepped-Wedge Cluster Randomised Controlled Trial
- Validation of the Candrive Older Driver Risk Stratification Tool for Assessing Medical Fitness-to-Drive in Older Australian Drivers
- Tms-evoked potentials: Neurophysiological biomarkers for diagnosis and prediction of response to ventriculoperitoneal shunt in normal pressure hydrocephalus
- Assessing the Feasibility and Efficacy of Virtual Reality Navigational Training for Older Adults
- A personalised health intervention to maintain independence in older people with mild frailty: a process evaluation within the HomeHealth RCT
- Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
- Aging of gray matter microstructure: A brain-wide characterization of age group differences using NODDI
- Designing a tip card to facilitate the use of a voice-activated assistant (VAA) for prospective memory support
- Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging
- Environmental Enrichment and Health Outcomes Among Low-Grade Glioma Brain Tumor Survivors
- Hearing and cognitive scores measured with the Montreal Cognitive Assessment Scale in The HUNT Study, Norway
- Sensory reweighting of postural control requires distinct rambling and trembling sway adaptations
- Alterations of Cortical Structure and Neurophysiology in Parkinson's Disease Are Aligned with Neurochemical Systems
- Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies
- Can Neighborhood Social Infrastructure Modify Cognitive Function? A Mixed-Methods Study of Urban-Dwelling Aging Americans
- Depth- and curvature-based quantitative susceptibility mapping analyses of cortical iron in Alzheimer’s disease
- Adaptative computerized cognitive training decreases mental workload during working memory precision task - A preliminary fNIRS study
- Intranasal esketamine in treatment-resistant depression with and without comorbid borderline personality disorder: A multicenter real-world longitudinal study
- Physiotherapy management of Long-COVID: an evidence-based approach
- The Hippocampus Links Episodic Memory and Bodily Awareness
- Trajectories of emotional and physical distress during ICU stay and their association with clinical factors and cognitive status at discharge
- Global network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages
- Mild Cognitive Impairment
- Pre‐transplant cognitive screening is a poor predictor of post‐transplant cognitive status
- Multivariate MR Biomarkers Better Predict Cognitive Dysfunction in Mouse\n Models of Alzheimers Disease
- Biomarkers of brain diseases
- Dementia and Cognitive Impairment
- Reduced interhemispheric transfer in older adults: Evidence from a divided visual field one-back task.
- Impact of cognitive load on pupil dilation: A comparative study of young and older adults
- Pitfalls and Limits in Automatic Dementia Assessment
- Effects of subjective perceptions of indoor visual environment on visual-related physical health of older people in residential care homes
- When Deep Learning Fails: Limitations of Recurrent Models on Stroke-Based Handwriting for Alzheimer's Disease Detection
- Topography of small vessel cerebrovascular disease differentially impacts cognitive domains across cognitive syndromes
- A Teleneuropsychological Battery for Assessing Older Panamanian Adults: Protocol for a Cross-Sectional Pilot Feasibility Study
- High rates of cognitive dysfunction and psychological symptoms despite good neurological outcome after aneurysmal subarachnoid haemorrhage: an observational study
- Novel variants in CSF1R associated with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)
- Promoting Healthy Ageing through Choral Training: A 9-Month Multidomain Intervention (MultiMusic) Enhances Neural Processing Speed in Community-Dwelling Older Adults
- Using functional near-infrared spectroscopy to study neurocognitive function in adult survivors of childhood acute lymphoblastic leukemia, an exploratory study
- Risk Factors for Cognitive Impairment in Adults Attending Australian Community‐Based Substance Use Treatment Services
- Deficient GABABergic and glutamatergic excitability in the motor cortex of patients with long-COVID and cognitive impairment
- The effects of prediabetes and type 2 diabetes mellitus on cognitive status, physical function, and fatigue in older adults: a case-control study
- Optimizing Differential Identifiability Improves Connectome Predictive Modeling of Cognitive Deficits in Alzheimer's Disease
- Bevacizumab Monotherapy Reduces Radiation-induced Brain Necrosis in Nasopharyngeal Carcinoma Patients: A Randomized Controlled Trial
- Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans. [europepmc]
- Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. [europepmc]
- Delirium in elderly people. [europepmc]
- Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models. [europepmc]
- The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT). [europepmc]
- Dementia and cognitive impairment: epidemiology, diagnosis, and treatment. [europepmc]
- The diagnosis and management of mild cognitive impairment: a clinical review. [europepmc]
- Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination for assessment of mild cognitive impairment in older adults. [europepmc]
- Lewy body dementias. [europepmc]
- Mild Cognitive Impairment. [europepmc]
- Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial. [europepmc]
- On the path to 2025: understanding the Alzheimer's disease continuum. [europepmc]
- Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). [europepmc]
- The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort. [europepmc]
- Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial. [europepmc]
- Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study. [europepmc]
- Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. [europepmc]
- Diagnosis and Management of Dementia: Review. [europepmc]
- Domains of cognition and their assessment . [europepmc]
- Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease. [europepmc]
- Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge. [europepmc]
- Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19. [europepmc]
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care. [europepmc]
- A comparison of the Mini-Mental State Examination (MMSE) with the Montreal Cognitive Assessment (MoCA) for mild cognitive impairment screening in Chinese middle-aged and older population: a cross-sectional study. [europepmc]
- Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms. [europepmc]
Related