2023/08/16 by Yifei Wang, Yerbol Palzhanov, Wang, Yifei +9 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Advanced biosensing and bioanalysis techniques #Computational Physics (physics.comp-ph) #FOS: Mathematics #FOS: Physical sciences #Lipid Membrane Structure and Behavior #Numerical Analysis (math.NA) #RNA Interference and Gene Delivery #Soft Condensed Matter (cond-mat.soft)
paper · pdf · doi:10.48550/arxiv.2308.08425
openalex publication_date 2023/08/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
This paper studies the fusogenicity of cationic liposomes in relation to their surface distribution of cationic lipids and utilizes membrane phase separation to control this surface distribution. It is found that concentrating the cationic lipids into small surface patches on liposomes, through phase-separation, can enhance liposome's fusogenicity. Further concentrating these lipids into smaller patches on the surface of liposomes led to an increased level of fusogenicity. These experimental findings are supported by numerical simulations using a mathematical model for phase-separated charged liposomes. Findings of this study may be used for design and development of highly fusogenic liposomes with minimal level of toxicity.