Predicting Mesoscopic Larmor Frequency Shifts in White Matter with Diffusion MRI -- A Monte-Carlo Study in axonal phantoms

2024/07/09 by Anders Dyhr Sandgaard, Sandgaard, Anders Dyhr, Sune Nørhøj Jespersen +1 · 1 citation
Medicine · #Advanced MRI Techniques and Applications #Biological Physics (physics.bio-ph) #FOS: Physical sciences #Medical Physics (physics.med-ph)

paper · pdf · doi:10.48550/arxiv.2407.06694

openalex publication_date 2024/07/09 · openalex created_date 2024/07/11 · openalex updated_date 2026/07/28

Abstract

This study aims to validate if MRI can measure anisotropic mesoscopic Larmor frequency shifts from white matter axonal microstructure relative to the B0 direction and if dMRI can estimate this anisotropy. Recent models describe how mesoscopic Larmor frequency shifts depend on induced magnetic fields by axons, described by an orientation distribution function. Using Monte-Carlo simulations of MRI signals in mesoscopic white matter axon substrates, we show MRI can estimate this mesoscopic frequency shift and dMRI can estimate its orientation dependence.

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• Axonal microstructure and compartmentalization impact the orientation and time dependence of mesoscopic transverse relaxation

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