2024/04/22 by Peter Emil Carstensen, Jacob Bendsen, Carstensen, Peter Emil +7
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer, Lipids, and Metabolism #Cholesterol and Lipid Metabolism #Diabetes, Cardiovascular Risks, and Lipoproteins #FOS: Biological sciences #Quantitative Methods (q-bio.QM)
paper · pdf · doi:10.48550/arxiv.2404.13934
openalex publication_date 2024/04/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Cardiovascular diseases are the leading cause of death. Increased levels of plasma cholesterol are consistently associated with an increased risk of cardiovascular disease. As a result, it is imperative that studies are conducted to determine the best course of action to reduce whole-body cholesterol levels. A whole-body mathematical model for cholesterol metabolism and transport is proposed. The model can simulate the effects of lipid-lowering drugs like statins and anti-PCSK9. The model is based on ordinary differential equations and kinetic functions. It has been validated against literature data. It offers a versatile platform for designing personalized interventions for cardiovascular health management.