Transcriptome changes caused by loss of WAGO-4 is remembered in wild type offspring

2025/07/28 by Ann‐Sophie Seistrup, René F. Ketting, Jan Schreier +1
Biochemistry, Genetics and Molecular Biology · #Animal Genetics and Reproduction

paper · doi:10.17912/micropub.biology.001769

openalex publication_date 2025/07/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

deletion mutant to show that general changes to 22G-RNAs, the small RNA cofactor binding WAGO-4 , do not correlate with changes to mRNA levels. We also show that the function of WAGO-4 differs in L4 larvae and in adult worms, and, importantly, we show that mRNA misregulation caused by loss of WAGO-4 persists in wild-type offspring of deletion mutants for at least five generations.

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