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Dual Meta-Learning with Longitudinally Generalized Regularization for One-Shot Brain Tissue Segmentation Across the Human Lifespan

2023/08/13 by Yongheng Sun, Fan Wang, Sun, Yongheng +8 · 2 citations
Computer Science · Engineering · Neuroscience · #Artificial Intelligence (cs.AI) #Brain Tumor Detection and Classification #Computer Vision and Pattern Recognition (cs.CV) #Domain Adaptation and Few-Shot Learning #FOS: Computer and information sciences #Medical Imaging and Analysis

paper · pdf · doi:10.48550/arxiv.2308.06774

openalex publication_date 2023/08/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Brain tissue segmentation is essential for neuroscience and clinical studies. However, segmentation on longitudinal data is challenging due to dynamic brain changes across the lifespan. Previous researches mainly focus on self-supervision with regularizations and will lose longitudinal generalization when fine-tuning on a specific age group. In this paper, we propose a dual meta-learning paradigm to learn longitudinally consistent representations and persist when fine-tuning. Specifically, we learn a plug-and-play feature extractor to extract longitudinal-consistent anatomical representations by meta-feature learning and a well-initialized task head for fine-tuning by meta-initialization learning. Besides, two class-aware regularizations are proposed to encourage longitudinal consistency. Experimental results on the iSeg2019 and ADNI datasets demonstrate the effectiveness of our method. Our code is available at https://github.com/ladderlab-xjtu/DuMeta.

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