2015/05/05 by Brendon Stubbs, B. Stubbs, D. Vancampfort +4 · 243 citations
Medicine · #Biology #Confidence interval #Diabetes Management and Education #Diabetes Management and Research #Diabetes mellitus #Endocrinology #Internal medicine #MEDLINE #Medicine #Mental health #Mental illness #Meta-analysis #Psychiatry #Relative risk #Schizophrenia (object-oriented programming) #Schizophrenia research and treatment #Subgroup analysis #Systematic review #Type 2 Diabetes Mellitus
paper · doi:10.1111/acps.12439
published in Acta Psychiatrica Scandinavica 132(2), 144-157 (Wiley)
openalex publication_date 2015/05/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
OBJECTIVE: To conduct a meta-analysis investigating the prevalence of type two diabetes mellitus (T2DM) in people with schizophrenia compared to controls. METHOD: Systematic review of electronic databases from inception till November 2014. Articles reporting the prevalence of T2DM in people with schizophrenia and healthy controls (without mental illness) were included. Two independent authors conducted searches and extracted data. A random effects relative risks (RR) meta-analysis was conducted. RESULTS: Twenty-five studies including 145,718 individuals with schizophrenia (22.5-54.4 years) and 4,343,407 controls were included. The prevalence of T2DM in people with schizophrenia was 9.5% (95% CI = 7.0-12.8, n = 145,718) and 10.75% (95% CI 7.44-14.5%, n = 2698) in studies capturing T2DM according to recognized criteria. The pooled RR across all studies was 1.82 (95% CI = 1.56-2.13; = 4,489,125). Subgroup analyses found a RR of 2.53 (95% CI = 1.68-3.799, n = 17,727) in studies ascertaining T2DM according to recognized criteria and RR 1.65 (95% CI = 1.34-2.03, n = 4,243,389) in studies relying on T2DM determined through medical records. CONCLUSION: People with schizophrenia are at least double the risk of developing T2DM according to recognized T2DM criteria. Proactive lifestyle and screening programmes should be given clinical priority.