1984/06/01 by M. McInnis, M. G. McInnis, H. Petursson +1 · 2 citations
Medicine · Psychology · #Anesthesia #Anticholinergic #Antipsychotic #Anxiety #Benztropine #Discontinuation #Electroconvulsive Therapy Studies #Extrapyramidal symptoms #Internal medicine #Medicine #Pathogenesis and Treatment of Hiccups #Placebo #Psychiatry #Psychology #Schizophrenia (object-oriented programming) #Schizophrenia research and treatment #Trihexyphenidyl
paper · doi:10.1111/j.1600-0447.1984.tb02528.x
openalex publication_date 1984/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/26
Trihexyphenidyl, a synthetic anticholinergic, is frequently used concurrently with neuroleptics to control extrapyramidal side effects. We present two case reports of trihexyphenidyl abuse which concur with the increasing concern expressed regarding the abuse potential of trihexyphenidyl. In one of the cases a double-blind, placebo-controlled withdrawal was conducted and monitored on a number of physiological parameters and the Hamilton Anxiety Rating Scale. A recognizable withdrawal syndrome followed discontinuation of the drug. In addition to the abuse potential it is suggested that dependence liability be considered in maintenance therapy with trihexyphenidyl and other antiparkinsonians.