1971/02/01 by J. Ditzel J. Kampmann, JP Kampmann · 3 citations
Medicine · #Blood properties and coagulation #Erythrocyte Function and Pathophysiology
paper · doi:10.1111/j.1748-1716.1971.tb04899.x
Abstract Whole‐blood viscosity was measured at six fixed shear rates with a cone‐plate viscometer. The 90 healthy subjects were evenly divided as to sex in three age groups from 15 to 80 years. They were selected by the criteria: normal haematocrit, erythrocyte sedimentation rate, serum creatinine concentration, and degree of intravascular erythrocyte aggregation evaluated by con‐junctival biomicroscopy; and free of disease affecting known rheological properties of the blood. The viscosity was higher in males than in females. Age was not consistently related to whole‐blood viscosity except that women of the oldest age group had a higher whole‐blood viscosity at two isolated shear rates than women in the youngest group and the plasma fibrinogen concentration was higher in the old than in the young women. A stepwise regression analysis of rheological factors and whole‐blood viscosity showed that the hematocrit had by far the closest relation to the whole‐blood viscosity at all shear rates. In the order of decreasing influence were the alpha‐globulins, fibrinogen, and serum albumin. There was a sex difference in that the whole‐blood viscosity of men was related to the concentration of alphas‐globulin, whereas in women the relation was to the alphai‐globulin.