A network of core and subtype-specific gene expression programs in myositis

2021/09/09 by David R. Amici, Iago Pinal‐Fernandez, Iago Pinal-Fernandez +4 · 26 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Inflammatory Myopathies and Dermatomyositis #Muscle Physiology and Disorders #RNA Research and Splicing

paper · doi:10.1007/s00401-021-02365-5

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• Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway
• Pathophysiological Mechanisms and Treatment of Dermatomyositis and Immune Mediated Necrotizing Myopathies: A Focused Review. [europepmc]
• The Genetics of Autoimmune Myositis. [europepmc]
• Inclusion body myositis: evolving concepts. [europepmc]
• Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor induced myositis. [europepmc]
• Transcriptional derepression of CHD4/NuRD-regulated genes in the muscle of patients with dermatomyositis and anti-Mi2 autoantibodies. [europepmc]
• Shared and Distinctive Transcriptomic and Proteomic Pathways in Adult and Juvenile Dermatomyositis. [europepmc]
• Neuromuscular disease: 2022 update. [europepmc]
• Integrated Multi-Omics Analysis for Inferring Molecular Players in Inclusion Body Myositis. [europepmc]
• A comprehensive review of dermatomyositis treatments - from rediscovered classics to promising horizons. [europepmc]
• Pathological autoantibody internalisation in myositis. [europepmc]
• Distinct Transcript-Level Expression Profiles and Unique Alternative Splicing in Inflammatory Myopathies. [europepmc]
• Recent Updates on the Pathogenesis of Inflammatory Myopathies. [europepmc]
• Experimental myositis: an optimised version of C-protein-induced myositis. [europepmc]
• Enhanced systemic oxidative stress response in patients with idiopathic inflammatory myopathies. [europepmc]
• A neuromuscular clinician's primer on machine learning. [europepmc]
• The role of monocytes and macrophages in idiopathic inflammatory myopathies: insights into pathogenesis and potential targets. [europepmc]
• Disease Activity-Dependent Siglec-1 Expression on Monocyte Subsets of Patients with Idiopathic Inflammatory Myopathies. [europepmc]
• Treatment of Immune-Mediated Necrotizing Myopathy. [europepmc]
• Identification of a distinctive gene signature associated with disease activity in granulomatous myositis. [europepmc]
• Altered Iron Regulation and the Role of Ferritin Heavy Chain in Dermatomyositis Patients. [europepmc]
• Vasculitic fasciitis characterizes a distinct subset of vasculitic myopathy with interferon-gamma signature. [europepmc]
• Immune-Driven Expression in Inclusion Body Myositis With T-Cell Large Granular Lymphocytic Leukemia. [europepmc]
• Ageing-Associated Dysregulation of Myogenic Differentiation in Inclusion Body Myositis. [europepmc]
• Myeloid dendritic cell subsets characterise muscle in patients with inclusion body myositis and correlate with the IFN-γ pathway and effector T cell markers. [europepmc]
• Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway. [europepmc]