The lysosomal function of progranulin, a guardian against neurodegeneration

2018/05/09 by Daniel H. Paushter, Huan Du, Tuancheng Feng +1 · 28 citations
Medicine · #Amyotrophic Lateral Sclerosis Research #Parkinson's Disease Mechanisms and Treatments #Alzheimer's disease research and treatments

paper · doi:10.1007/s00401-018-1861-8

Citations

• Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis
• Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage

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• LRP10 promotes trafficking of progranulin and prosaposin to lysosomes
• Lysosomal enzyme processing and trafficking in the social amoeba Dictyostelium discoideum
• New insights into the genetic etiology of Alzheimer’s disease and related dementias
• Emerging new roles of the lysosome and neuronal ceroid lipofuscinoses. [europepmc]
• Regulatory Roles of Sortilin and SorLA in Immune-Related Processes. [europepmc]
• Progranulin: A conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseases. [europepmc]
• Microglial Progranulin: Involvement in Alzheimer's Disease and Neurodegenerative Diseases. [europepmc]
• Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. [europepmc]
• Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice. [europepmc]
• Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology. [europepmc]
• Friend, Foe or Both? Immune Activity in Alzheimer's Disease. [europepmc]
• Progranulin inhibits LPS-induced macrophage M1 polarization via NF-кB and MAPK pathways. [europepmc]
• Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice. [europepmc]
• Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. [europepmc]
• Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism. [europepmc]
• Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy. [europepmc]
• Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders. [europepmc]
• Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8 + T cell exclusion. [europepmc]
• 'The long tail of Covid-19' - The detection of a prolonged inflammatory response after a SARS-CoV-2 infection in asymptomatic and mildly affected patients. [europepmc]
• Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis. [europepmc]
• Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD. [europepmc]
• Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic. [europepmc]
• Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. [europepmc]
• New insights into the genetic etiology of Alzheimer's disease and related dementias. [europepmc]
• Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease. [europepmc]
• Frontotemporal Dementia, Where Do We Stand? A Narrative Review. [europepmc]
• Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons. [europepmc]
• Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease. [europepmc]