Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons

2022/12/09 by Sebastiaan Moonen, Marta J. Koper, Evelien Van Schoor +8 · 30 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Inflammasome and immune disorders #Alzheimer's disease research and treatments #Calcium signaling and nucleotide metabolism

paper · doi:10.1007/s00401-022-02528-y

Citations

• Neuropathological stageing of Alzheimer-related changes
• Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
• Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

Cited by

• The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease
• Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis
• Copper Overload Promotes β-amyloid Induced NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis in Alzheimer’s Disease
• Caspases in Alzheimer’s Disease: Mechanism of Activation, Role, and Potential Treatment
• Role of pyroptosis in the pathogenesis of various neurological diseases
• Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review. [europepmc]
• The innate immune response in tauopathies. [europepmc]
• What type of cell death occurs in chronic cerebral hypoperfusion? A review focusing on pyroptosis and its potential therapeutic implications. [europepmc]
• Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology. [europepmc]
• Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer's disease? [europepmc]
• Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-κB-NLRP3 axis. [europepmc]
• FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease. [europepmc]
• The Impact of Neurotransmitters on the Neurobiology of Neurodegenerative Diseases. [europepmc]
• Caspases in Alzheimer's Disease: Mechanism of Activation, Role, and Potential Treatment. [europepmc]
• Role of pyroptosis in the pathogenesis of various neurological diseases. [europepmc]
• The gasdermin family: emerging therapeutic targets in diseases. [europepmc]
• The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms. [europepmc]
• Focusing on mitochondria in the brain: from biology to therapeutics. [europepmc]
• The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disease. [europepmc]
• Fluvoxamine maleate alleviates amyloid-beta load and neuroinflammation in 5XFAD mice to ameliorate Alzheimer disease pathology. [europepmc]
• Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. [europepmc]
• Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging. [europepmc]
• Pyroptosis in health and disease: mechanisms, regulation and clinical perspective. [europepmc]
• Caspase-8 in inflammatory diseases: a potential therapeutic target. [europepmc]
• The PANoptosis-related hippocampal molecular subtypes and key biomarkers in Alzheimer's disease patients. [europepmc]
• Neuroinflammation in Alzheimer disease. [europepmc]
• Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline. [europepmc]
• HERV-W Env Induces Neuron Pyroptosis via the NLRP3-CASP1-GSDMD Pathway in Recent-Onset Schizophrenia. [europepmc]
• Alzheimer's disease neuropathology and its estimation with fluid and imaging biomarkers. [europepmc]
• Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications. [europepmc]