Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

2015/03/09 by Andrey Korshunov, Marina Ryzhova, Volker Hovestadt +19 · 28 citations
Medicine · #Glioma Diagnosis and Treatment #Pancreatic and Hepatic Oncology Research #Neuroblastoma Research and Treatments

paper · doi:10.1007/s00401-015-1405-4

Cited by

• Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma
• The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors
• Integrated molecular characterization of IDH‐mutant glioblastomas
• Epithelioid Glioblastomas and Anaplastic Epithelioid Pleomorphic Xanthoastrocytomas--Same Entity or First Cousins? [europepmc]
• Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. [europepmc]
• Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation. [europepmc]
• Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma. [europepmc]
• Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. [europepmc]
• Genomic Insights into Diffuse Intrinsic Pontine Glioma. [europepmc]
• Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. [europepmc]
• Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis. [europepmc]
• Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience. [europepmc]
• The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. [europepmc]
• Advances in the classification of pediatric brain tumors through DNA methylation profiling: From research tool to frontline diagnostic. [europepmc]
• Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location. [europepmc]
• High frequency of H3 K27M mutations in adult midline gliomas. [europepmc]
• Childhood brain tumors: current management, biological insights, and future directions. [europepmc]
• ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma. [europepmc]
• Oncogenic BRAF Alterations and Their Role in Brain Tumors. [europepmc]
• Imaging signatures of glioblastoma molecular characteristics: A radiogenomics review. [europepmc]
• BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors. [europepmc]
• High-grade gliomas in adolescents and young adults highlight histomolecular differences from their adult and pediatric counterparts. [europepmc]
• Pediatric low-grade glioma in the era of molecular diagnostics. [europepmc]
• Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adults. [europepmc]
• Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults. [europepmc]
• PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum. [europepmc]
• Prognostic and Predictive Biomarkers in Gliomas. [europepmc]
• H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models. [europepmc]