Genetic similarity versus genetic ancestry groups as sample descriptors in human genetics

2022/07/23 by Graham Coop, Coop, Graham · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · #FOS: Biological sciences #Genetic Associations and Epidemiology #Nutrition, Genetics, and Disease #Populations and Evolution (q-bio.PE) #q-bio.PE

paper · pdf · doi:10.48550/arxiv.2207.11595

openalex publication_date 2022/07/23 · arxiv published 2022/07/23 · openalex created_date 2022/07/28 · arxiv updated 2023/01/07 · openalex updated_date 2026/07/28

Abstract

A common sample descriptor in human genomics studies is that of 'genetic ancestry group', with terms such as 'European genetic ancestry' or 'East Asian genetic ancestry' frequently used in publications to describe the genetics of groups of individuals based on the analysis of their genotypes. In this Perspective, I argue that these terms are imprecise and potentially misleading and that, for most applications, simple statements of genetic similarity represent a more accurate description.

Cited by

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• The distribution of highly deleterious variants across human ancestry groups

Discussions

• yep arxiv accepts opinion/review pieces etc, e.g. under quantbio grouping: arxiv.org/abs/2207.11595 There's also socopen.org and ecoevorxiv.org and a number of others. Choice might depend on what t [bsky, 2 points, 2 comments]

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