2012/12/05 by Kehong Zhang, Zhang, Kehong, Kaifu Luo +1
Biochemistry, Genetics and Molecular Biology · Engineering · Physics and Astronomy · #Biological Physics (physics.bio-ph) #Biomolecules (q-bio.BM) #FOS: Biological sciences #FOS: Physical sciences #Force Microscopy Techniques and Applications #Ion-surface interactions and analysis #Nanopore and Nanochannel Transport Studies #Soft Condensed Matter (cond-mat.soft) #Statistical Mechanics (cond-mat.stat-mech) #cond-mat.soft #cond-mat.stat-mech #physics.bio-ph #q-bio.BM
paper · pdf · doi:10.48550/arxiv.1212.1052
8 pages, 7 figures, accepted to Soft Matter
arxiv created 2012/12/05 · openalex publication_date 2012/12/05 · arxiv updated 2012/12/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Using Langevin dynamics simulations, we investigate the dynamics of a flexible polymer translocation into a confined area under a driving force through a nanopore. We choose an ellipsoidal shape for the confinement and consider the dependence of the asymmetry of the ellipsoid measured by the aspect ratio on the translocation time. Compared with an isotropic confinement (sphere), an anisotropic confinement (ellipsoid) with the same volume slows down the translocation, and the translocation time increases with increasing the aspect ratio of the ellipsoid. We further find that it takes different time for polymer translocation into the same ellipsoid through major-axis and minor-axis directions, depending on the average density of the whole chain in the ellipsoid, ϕ. For ϕ lower than a critical value ϕc, the translocation through minor axis is faster, and vice versa. These complicated behaviors are interpreted by the degree of the confinement and anisotropic confinement induced folding of the translocated chain.