Link-weight distribution of microRNA co-target networks exhibit universality

2013/07/04 by Basu, Mahashweta, Bhattacharyya, Nitai P., Mohanty, P. K.
#Biological Physics (physics.bio-ph) #FOS: Biological sciences #FOS: Physical sciences #Molecular Networks (q-bio.MN)

paper · doi:10.48550/arxiv.1307.1382

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression by binding to the 3' UTR of the corresponding messenger RNAs. We construct miRNA co-target networks for 22 different species using a target prediction database, MicroCosm Tagets. The miRNA pairs of individual species having one or more common target genes are connected and the number of co-targets are assigned as the weight of these links. We show that the link-weight distributions of all the species collapse remarkably onto each other when scaled suitably. It turns out that the scale-factor is a measure of complexity of the species. A simple model, where targets are chosen randomly by miRNAs, could provide the correct scaling function and explain the universality.

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