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Light-tunable optical cell manipulation via photoactive azobenzene-containing thin film bio-substrate

2020/12/01 by Olivier Lefèbvre, Lefebvre, Olivier, Mireille Lambert +13
Agricultural and Biological Sciences · Neuroscience · #Cephalopods and Marine Biology #FOS: Physical sciences #Materials Science (cond-mat.mtrl-sci) #Photoreceptor and optogenetics research #Plant and Biological Electrophysiology Studies

paper · doi:10.48550/arxiv.2012.00405

openalex publication_date 2020/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

In-vivo, real-time study of the local and collective cellular biomechanical responses requires the fine and selective manipulation of the cellular environment. One innovative pathway is the use of photoactive bio-substrates such as azobenzene-containing materials, which exhibit spectacular photomechanical properties, to optically trigger the local, mechanical stimulation of cells. Excited cells exhibit spectacular morphological modifications and area shrinkage, which are dependent on the illumination. This demonstrates the capabilities of photomechanically active substrates to study the phenomena resulting from the mechanical interaction of cells with their environment.

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