2018/02/22 by Zhang, Chuan, Ge, Lulu, You, Xiaohu
#Chemical Physics (physics.chem-ph) #FOS: Biological sciences #FOS: Physical sciences #Molecular Networks (q-bio.MN)
paper · doi:10.48550/arxiv.1802.07914
Timing is of fundamental importance in biology and our life. Borrowing ideas from mechanism, we map our clock signals onto a gear system, in pursuit of better depiction of a clock signal implemented with chemical reaction networks (CRNs). On a chassis of gear theory, more quantitative descriptions are offered for our method. Inspired by gears, our work to synthesize a tunable clock signal could be divided into two parts. Part I, this paper, mainly focuses on the implementation of clock signals with three types of duty cycles, namely 1/2, 1/N (N > 2), and M/N. Part II devotes itself in addressing frequency alteration issues of clock signals. \textcolorblackGuaranteed by existing literature, the experimental chassis can be taken care of by DNA strand displacement reactions, which lay a solid foundation for the physical implementation of nearly arbitrary CRNs.