Enantioselective Organocatalytic Transfer Hydrogenation Reactions using Hantzsch Esters

2007/12/01 by Stéphane G. Ouellet, Abbas M. Walji, David W. C. Macmillan +1 · 539 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Asymmetric Hydrogenation and Catalysis #Asymmetric Synthesis and Catalysis #Catalysis #Chemical Synthesis and Analysis #Chemistry #Combinatorial chemistry #Enantioselective synthesis #Iminium #Organic chemistry #Organocatalysis #Ruthenium #Transfer hydrogenation

paper · doi:10.1021/ar7001864

published in Accounts of Chemical Research 40(12), 1327-1339 (American Chemical Society)

openalex publication_date 2007/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Abstract

Within the realm of catalytic asymmetric hydrogenation, the focus continues to be on the use of chiral metal complexes in conjunction with a hydrogen source. Recently, the widespread development of organocatalysis, including the invention of iminium activation, has led to the discovery of many new enantioselective transformations. Based on this strategy, a number of bioinspired processes for the enantioselective organocatalytic transfer hydrogenation of alpha,beta-unsaturated carbonyl compounds and imines have been discovered. These topics will be the focus of this Account.

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