Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia

2018/09/03 by Megan L. Gill, Peter J. Grahn, Jonathan S. Calvert +16 · 1 voice · 31 citations
Medicine · #Spinal Cord Injury Research #Stroke Rehabilitation and Recovery #Nerve Injury and Rehabilitation

paper · doi:10.1038/s41591-018-0175-7

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• Fundamental limitations of kilohertz-frequency carriers in afferent fibre recruitment with transcutaneous spinal cord stimulation
• Control of Forelimb and Hindlimb Movements and Their Coordination during Quadrupedal Locomotion across Speeds in Adult Spinal Cats
• Decoding of the Walking States and Step Rates from Cortical Electrocorticogram Signals
• Electrophysiological Guidance of Epidural Electrode Array Implantation over the Human Lumbosacral Spinal Cord to Enable Motor Function after Chronic Paralysis. [europepmc]
• Myelin status and oligodendrocyte lineage cells over time after spinal cord injury: What do we know and what still needs to be unwrapped? [europepmc]
• Regenerative Therapies for Spinal Cord Injury. [europepmc]
• Enhancing rehabilitation and functional recovery after brain and spinal cord trauma with electrical neuromodulation. [europepmc]
• Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord. [europepmc]
• Recovery cycles of posterior root-muscle reflexes evoked by transcutaneous spinal cord stimulation and of the H reflex in individuals with intact and injured spinal cord. [europepmc]
• Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019). [europepmc]
• Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation. [europepmc]
• Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury. [europepmc]
• Strategies and prospects of effective neural circuits reconstruction after spinal cord injury. [europepmc]
• Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury. [europepmc]
• Recent advances in bioelectronics chemistry. [europepmc]
• Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury. [europepmc]
• Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord. [europepmc]
• Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease. [europepmc]
• Control of Mammalian Locomotion by Somatosensory Feedback. [europepmc]
• Regulating Endogenous Neural Stem Cell Activation to Promote Spinal Cord Injury Repair. [europepmc]
• Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury. [europepmc]
• Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons. [europepmc]
• Pathophysiology and Therapeutic Approaches for Spinal Cord Injury. [europepmc]
• Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis. [europepmc]
• Walking naturally after spinal cord injury using a brain-spine interface. [europepmc]
• Drug delivery to the central nervous system. [europepmc]
• Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial. [europepmc]
• Long-Term Spinal Cord Stimulation After Chronic Complete Spinal Cord Injury Enables Volitional Movement in the Absence of Stimulation. [europepmc]

Discussions

• Neuromodulation of spinal networks enables stepping after complete paraplegia [hn, 87 points, 13 comments]