2016/10/25 by Saeed Reza Hajian, Ali Abbaspour Tehrani Fard, Hajian, Saeed Reza +5
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Advanced MRI Techniques and Applications #FOS: Physical sciences #Medical Physics (physics.med-ph) #Spectroscopy Techniques in Biomedical and Chemical Research #Ultrasound Imaging and Elastography #Ultrasound and Hyperthermia Applications
paper · pdf · doi:10.48550/arxiv.1610.08036
openalex publication_date 2016/10/25 · openalex created_date 2022/08/31 · openalex updated_date 2026/07/28
In high intensity focused ultrasound (HIFU) systems using non-ionizing\nmethods in cancer treatment, if the device is applied to the body externally,\nthe HIFU beam can damage nearby healthy tissues and burn skin due to lack of\nknowledge about the viscoelastic properties of patient tissue and failure to\nconsider the physical properties of tissue in treatment planning. Addressing\nthis problem by using various methods, such as MRI or ultrasound, elastography\ncan effectively measure visco-elastic properties of tissue and fits within the\npattern of stimulation and total treatment planning. In this paper, in a linear\npath of HIFU propagation, and by considering the smallest part of the path,\nincluding voxel with three mechanical elements of mass, spring and damper,\nwhich represents the properties of viscoelasticity of tissue, by creating waves\nof HIFU in the wire environment of MATLAB mechanics and stimulating these\nelements, pressure and heat transfer due to stimulation in the hypothetical\nvoxel was obtained. Through the repeatability of these three-dimensional\nelements, tissue is created. The measurement was performed on three layers. The\nvalues of these elements for liver tissue and kidney of sheep in a practical\nexample and outside the body are measured, and pressure and heat for three\nlayers of liver and kidney tissue of an organism were obtained by applying\nultrasound signals with a designed model. This action is repeated in three\ndifferent directions, and the results are then compared with simulation\nsoftware for ultrasound, as a reference to U.S. Food and Drug Administration\n(FDA) measures for HIFU, as well as comparisons of results with an operational\nmethod for an HIFU cell.\n