Calculations of the cell survival rate after irradiating with minibeams of protons and ¹²C

2024/11/21 by Aleksandr Svetlichnyi, Svetlichnyi, A. O., S. D. Savenkov +3
Agricultural and Biological Sciences · Medicine · #FOS: Physical sciences #Medical Physics (physics.med-ph) #Plant Genetic and Mutation Studies #Radiation Effects and Dosimetry #Radiation Therapy and Dosimetry

paper · pdf · doi:10.48550/arxiv.2411.14589

openalex publication_date 2024/11/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

The propagation of minibeams of protons and ¹²C in a water phantom was modelled with Geant4 v10.3, and the survival probabilities of human salivary gland cells representing healthy and tumour tissues of normal radiosensitivity were calculated with the modified microdosimetric kinetic model. The advantage of minibeams over homogeneous irradiation in sparing healthy tissues proximal to the tumour was demonstrated. Survival-volume histograms were proposed to quantify the difference in the survival probability of cells inside and outside the minibeam spots.

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