2019/11/14 by Priyanka Patki, Patki, Priyanka, Francesco Di Costanzo +1
Engineering · #Biological Physics (physics.bio-ph) #Bone Tissue Engineering Materials #Computational Engineering #Computational Physics (physics.comp-ph) #FOS: Computer and information sciences #FOS: Physical sciences #Finance #and Science (cs.CE)
paper · pdf · doi:10.48550/arxiv.1912.06195
openalex publication_date 2019/11/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We derive a mixture theory-based mathematical model of the degradation of a poroelastic solid immersed in a fluid bath. The evolution of the solid's mechanical and transport properties are also modeled. The inspiration for the model is the study of the temporal evolution of biodegradable Tissue Engineered Nerve Guides (TENGs), which are surgical implants supporting the alignment and re-growth of damaged nerves. The model comprises of the degrading solid, the degradation reaction products, and the fluid in which the solid is immersed. The weak formulation of the partial differential equations (PDEs) so derived is numerically implemented using a Finite Element Method (FEM). The numerical model is studied for stability and convergence rates using the Method of Manufactured Solutions.