2023/06/13 by Nick Ruben Neuling, Neuling, Nick Ruben, Robin D. Allert +3
Engineering · Materials Science · Physics and Astronomy · #Advanced Memory and Neural Computing #Applied Physics (physics.app-ph) #Diamond and Carbon-based Materials Research #FOS: Physical sciences #Magnetic properties of thin films
paper · pdf · doi:10.48550/arxiv.2306.07593
openalex publication_date 2023/06/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03
Single-cell analysis can unravel functional heterogeneity within cell populations otherwise obscured by ensemble measurements. However, non-invasive techniques that probe chemical entities and their dynamics are still lacking. This challenge could be overcome by novel sensors based on nitrogen-vacancy (NV) centers in diamond, which enable nuclear magnetic resonance (NMR) spectroscopy on unprecedented sample volumes. In this perspective, we briefly introduce NV-based quantum sensing and review the progress made in microscale NV-NMR spectroscopy. Lastly, we discuss approaches to enhance the sensitivity of NV ensemble magnetometers to detect biologically relevant concentrations and provide a roadmap towards their application in single-cell analysis.