2,2’-Bipyridine: An efficient organo-catalyst for the synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives

2024/09/05 by Momenpour Surchani, Mandana, Shirini, Farhad, Tajik, Hassan +1
#2 #2’-bipyridine #3-d]pyrimidines #One-pot synthesis #Organo-catalyst #Pyrano[2 #Pyrido[2

paper · doi:10.57647/j.ijc.2024.1403.27

Abstract

In this work, a highly efficient technique has been documented for the one-pot synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives. This method employs 2,2’-bipyridine as a cost-effective and proficient organo-catalyst. All reactions take place within reasonable reaction periods, yielding favorable to excellent results. The reusability of the catalyst is also investigated during the reactions. Moreover, a rational mechanism was suggested via GC-Mass analysis of the trapped intermediates. Research Highlights 2,2′-bipyridine as an excellent basic catalyst for the synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines in the aqua media. Simple procedure, short reaction times, and high yields. No column chromatographic separation, commercial availability and recyclability of the catalyst. Use of GC-Mass analysis for the confirmation of the proposed mechanism.

Related

• Vitamin C as an efficient and green homogeneous catalyst for the synthesis of pyride[2,3-d:5,6-d′] dipyrimidine derivatives
• One-pot synthesis of pyrimido[4,5-d]pyrimidine derivatives using a new DABCO-based ionic liquid catalyst
• Fe3O4@3-Aminopropyltriethoxysilane-SO3H: A greener catalyst for one-pot synthesis of pyranopyrimidine derivatives
• Synthetic protocols for non-fused pyrimidines
• Ionic Liquid-mediated Multi-component Reaction Towards the Synthesis of Dihydropyrimidones: An Environmentally Benign Green Protocol