2017/12/05 by M. Umar Qureshi, Qureshi, M. Umar, Mitchel J. Colebank +16
Medicine · #Cardiovascular Function and Risk Factors #Cardiovascular Health and Disease Prevention #FOS: Biological sciences #FOS: Physical sciences #Fluid Dynamics (physics.flu-dyn) #Pulmonary Hypertension Research and Treatments #Tissues and Organs (q-bio.TO)
paper · pdf · doi:10.48550/arxiv.1712.01699
openalex publication_date 2017/12/05 · openalex created_date 2022/10/06 · openalex updated_date 2026/07/28
This study uses a one dimensional fluid dynamics arterial network model to\ninfer changes in hemodynamic quantities associated with pulmonary hypertension\nin mice. Data for this study include blood flow and pressure measurements from\nthe main pulmonary artery for 7 control mice with normal pulmonary function and\n5 hypertensive mice with hypoxia induced pulmonary hypertension. Arterial\ndimensions for a 21 vessel network are extracted from micro-CT images of lungs\nfrom a representative control and hypertensive mouse. Each vessel is\nrepresented by its length and radius. Fluid dynamic computations are done\nassuming that the flow is Newtonian, viscous, laminar, and has no swirl. The\nsystem of equations is closed by a constitutive equation relating pressure and\narea, using a linear model derived from stress-strain deformation in the\ncircumferential direction assuming that the arterial walls are thin, and also\nan empirical nonlinear model. For each dataset, an inflow waveform is extracted\nfrom the data, and nominal parameters specifying the outflow boundary\nconditions are computed from mean values and characteristic time scales\nextracted from the data. The model is calibrated for each mouse by estimating\nparameters that minimize the least squares error between measured and computed\nwaveforms. Optimized parameters are compared across the control and the\nhypertensive groups to characterize vascular remodeling with disease. Results\nshow that pulmonary hypertension is associated with stiffer and less compliant\nproximal and distal vasculature with augmented wave reflections, and that\nelastic nonlinearities are insignificant in the hypertensive animal.\n