Dense Suspension Inertial Microfluidic Particle Theory (DENSE-IMPACT) Model for Elucidating Outer Wall Focusing at High Cell Densities

2024/09/19 by Lim, Soon Wei Daniel, Kee, Yong How, Smith, Scott Nicholas Allan +4
#Applied Physics (physics.app-ph) #FOS: Physical sciences #Fluid Dynamics (physics.flu-dyn)

paper · doi:10.48550/arxiv.2409.12488

Abstract

Inertial microfluidics has been limited to dilute particle concentrations due to defocusing (spreading out) at high particle concentrations. We observe a counterintuitive shift of focusing to the outer curved wall under high concentration flow, which contradicts the existing particle focusing theory. We developed a multiphase model incorporating lift forces and particle-particle interactions to explain this behaviour. Numerical simulations validated by experimental data reveal the shift is governed by the ratio of the lift force strength to that of particle interaction frequencies.

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