On the clustering of rare codons and its effect on translation

2009/10/02 by Lalit Ponnala, Ponnala, Lalit
Computer Science · Medicine · #Algorithms and Data Compression #Authorship Attribution and Profiling #Data-Driven Disease Surveillance #FOS: Biological sciences #Genomics (q-bio.GN) #Quantitative Methods (q-bio.QM)

paper · pdf · doi:10.48550/arxiv.0910.0429

openalex publication_date 2009/10/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

The presence of clusters of rare codons is known to negatively impact the efficiency and accuracy of protein production. In this paper, we demonstrate a statistical method of identifying such clusters in the coding sequence of a gene. Using E. coli as our model organism, we show that genes having denser clusters tend to have lower protein yields.

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