2005/02/15 by Marco Cosentino Lagomarsino, M. Cosentino Lagomarsino, Lagomarsino, M. Cosentino +4
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Bioinformatics and Genomic Networks #Disordered Systems and Neural Networks (cond-mat.dis-nn) #FOS: Biological sciences #FOS: Physical sciences #Gene Regulatory Network Analysis #Microbial Metabolic Engineering and Bioproduction #Molecular Networks (q-bio.MN) #cond-mat.dis-nn #q-bio.MN
paper · pdf · doi:10.48550/arxiv.q-bio/0502017
arxiv created 2005/02/15 · openalex publication_date 2005/02/15 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Identity, response to external stimuli, and spatial architecture of a living system are central topics of molecular biology. Presently, they are largely seen as a result of the interplay between a gene repertoire and the regulatory machinery of the cell. At the transcriptional level, the cis-regulatory regions establish sets of interdependencies between transcription factors and genes, including other transcription factors. These ``transcription networks'' are too large to be approached globally with a detailed dynamical model. In this paper, we describe an approach to this problem that focuses solely on the compatibility between gene expression patterns and signal integration functions, discussing calculations carried on the simplest, Boolean, realization of the model, and a first application to experimental data sets.